Self-Assembly of Amphiphilic Block Copolypeptoids – Micelles, Worms and Polymersomes
نویسندگان
چکیده
منابع مشابه
Self-Assembly of Amphiphilic Block Copolypeptoids – Micelles, Worms and Polymersomes
Polypeptoids are an old but recently rediscovered polymer class with interesting synthetic, physico-chemical and biological characteristics. Here, we introduce new aromatic monomers, N-benzyl glycine N-carboxyanhydride and N-phenethyl glycine N-carboxyanhydride and their block copolymers with the hydrophilic polysarcosine. We compare their self-assembly in water and aqueous buffer with the self...
متن کاملCorrigendum: Self-Assembly of Amphiphilic Block Copolypeptoids – Micelles, Worms and Polymersomes
“This work was supported by the Fonds der Chemischen Industrie and the Free State of Bavaria. The authors gratefully acknowledge financial support by the German Plastics Center SKZ and Julius-Maximilians Universität Würzburg for start-up funding. Light-scattering experiments were possible through support of the Deutsche Forschungsgemeinschaft (INST 93/774-1 FUGG). RL, CF and JG thank the Deutsc...
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Block copolymer nano-micelles are especially important in cancer treatment because of their fine dimensions. In this article, three systems of amphiphilic copolymers with similar lengths and different ratios of the hydrophobic and hydrophilic chains are studied using implicit-solvent coarse-grained molecular dynamics simulations. The factor fphil is defined as the ratio of the number...
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Poly(N-substituted glycine) "peptoids" constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small peptidomim...
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For the last decades, amphiphilic block copolymers have been at the focus of extensive scientific interest, due to their unique properties and numerous potential applications. Their technological potential evolves from their ability to self-assemble into a plethora of morphologically diverse nanostructures such as micelles, polymersomes, cylinders and others. In this chapter, we discuss the bas...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep33491